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KMID : 0604520190450030265
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Journal of the Society of Cosmetic Scientists of Korea
2019 Volume.45 No. 3 p.265 ~ p.275
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Skin Permeability of Petroselinum Crispum Extract Using Polymer Micelles and Epidermal Penetration Peptide
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An Gyu-Min
Park Su-In
Kim Min-Gi
Heo Soo-Hyeon
Shin Moon-Sam
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Abstract
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This study was conducted to investigate physiological activity and its skin permeability of Petroselinum crispum extract using polymer micelles and cell penetrating peptide. In the antioxidant test, the total concentrations of polyphenol compounds were determined to be 121.68 ± 2.49 mg/g (for ethanol extract and), 72.42 ± 1.52 mg/g (for hydrothermal extract.). The DPPH radical scavenging ability was 90.48 ± 0.46% (for ethanol extract) and 83.92 ± 0.13% (for hydrothermal extract) at 2000 mg/L. ABTS radical scavenging ability was 91.08 ± 0.14% for ethanol extract ethanol extract, which is higher than that of hydrothermal extract at 800 mg/L (69.63 ± 0.55%). In the SOD experiments, the P. crispum ethanol extract showed higher SOD activity than that of the P. crispum hydrothermal extract at all concentrations.. At a concentration of 16,000 mg/L, P. crispum ethanol extract showed the highest SOD activity of 128.45 ± 0.70%. The elastase inhibitory assay also showed concentration dependence and elastase inhibition of P. crispum ethanol extract was 99.99 ± 1.54%, which was the highest at 2,000 mg/L. To solve the problem of insolubility and to improve skin permeability of the extract, PCL-PEG polymer micelle containing P. crispum ethanol extracts and 1% cell permeable peptide, hexa-D-arginine (R6) were successfully prepared with a particle size of 40.10 nm. In the results of 24 hours of skin permeation experiment, total accumulated beta-carotene amounts showed 37.99 μg/cm² in Petroselinum crispum extracts and 68.38 μg/cm² (1.8 times) in P. crispum extract of the particles..
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KEYWORD
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antioxidant, ethanol extract, Petroselinum crispum, polymer micelle, skin permeability
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